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A causal link between obesity and autoimmune disease (3/8/2025) Concerning links between human papillomavirus (HPV) infection and male infertility (3/1/2025) A common nasal decongestant appears to be ineffective, so what alternatives exist? (2/22/2025) How can the process of drug development be improved? (2/15/2025) Compounding effects of multiple metabolic conditions on cardiovascular risk (2/8/2025) Unlocking the potential of migraine medications for endometriosis treatment (2/1/2025) Sleepless nights? Try boosting your physical activity level (1/25/2025) A nuanced and multifaceted approach to longevity research (1/18/2025) A link between antihypertensive medications and fall risk reminds us to take precautions (1/11/2025) The endless possibilities of living well in your marginal decade (1/4/2025) Using “atomic habits” to reach your health goals (12/28/2024) Research Worth Sharing, December 2024 Edition (12/21/2024) When caution becomes concerning: the relationship between health anxiety and mortality (12/14/2024) A rational look at a sensationalized sugar study (12/7/2024) Oldies-But-Goodies, December 2024 Edition (11/30/2024) Shingles and brain health: an emerging link or healthy user bias? (11/23/2024) Calming the concern over exercise duration and coronary artery calcification (11/16/2024) Radical extension of the human lifespan, science fiction or reality? (11/9/2024) Failure of resveratrol to improve metabolic health is another nail in the coffin for the alleged “anti-aging” compound (10/26/2024) Beyond the headlines: evaluating exercise as an equivalent to medication for the treatment of depression and anxiety (10/19/2024) Research Worth Sharing, October 2024 Edition (10/12/2024) Do humans age in distinct rapid bursts instead of gradually over time? (10/5/2024) High-intensity interval training and cognitive function in older adults: promising but limited findings (9/28/2024) Could plasma protein levels be a surrogate for VO2 max testing as a measure of cardiorespiratory fitness? (9/21/2024) A study suggesting that exercise does not impact mortality offers little more than click-bait (9/14/2024) Is interleukin-11 a promising new target for lifespan-extending interventions? (9/7/2024) A new blood test doesn’t change the game for colorectal cancer screening (8/31/2024) Back on the merry-go-round of bad science regarding meat consumption (8/24/2024) Coronary atherosclerosis is a silent killer, but we have tools to stop it (8/17/2024) A recent study does little to supplement earlier knowledge on multivitamins and health (8/10/2024) Oldies-But-Goodies, August 2024 Edition (8/3/2024) Does pharmacological treatment for ADHD increase risk of cardiovascular disease? (7/27/2024) Don’t underestimate the importance of oral health (7/20/2024) My recent lesson in overtraining – and in the power of seeing first-hand the impacts of positive health changes (7/13/2024) Research Worth Sharing, July 2024 Edition (7/6/2024) Does hormone replacement therapy impact dementia risk? (6/29/2024) Does xylitol increase risk of cardiovascular disease? (6/22/2024) Is Alzheimer’s disease unavoidable for individuals with a high-risk APOE genotype? (6/15/2024) Reducing heavy alcohol intake: a lifeline for cardiovascular health (6/8/2024) High Lp(a) warrants intervention, even without other cardiovascular risk factors (6/1/2024) Oldies-But-Goodies, May 2024 Edition (5/25/2024) When it comes to health, appearances can be deceiving: a lesson from egg boxing (5/18/2024) Can ovarian cancer be detected by genetic analysis of cervical cancer screening samples? (5/11/2024) With exercise, results matter more than “time served” (5/4/2024) Does the timing of sleep loss during the night impact subsequent negative metabolic effects? (4/27/2024) More “hack” than “bio”: why biohacking sends the wrong messages about the pursuit of health and longevity (4/20/2024) Silencing the alarm over a recent paper on dietary protein and atherosclerosis (4/13/2024) Resistance training partially reverses some of the hallmarks of aging type II muscle fibers (4/6/2024) Research Worth Sharing, March 2024 Edition (3/30/2024) Does time-restricted eating increase the risk of cardiovascular death? (3/23/2024) “DNA diets” are still a long way off from offering an easier route to weight loss (3/16/2024) Removing race as a risk factor for cardiovascular disease? (3/9/2024) Aerobic exercise for Parkinson’s disease (3/2/2024) A study comparing the effects of vegan and omnivorous diets fails Science 101 (2/24/2024) The loss of a rising marathoner is a tragic reminder of the toll of motor accidents (2/17/2024) Does low iron intake change exercise capacity? (2/10/2024) You’re never too old to start exercising – just ask a 93-year-old rowing champion (2/3/2024) New insights on maximizing protein utilization for muscle protein synthesis (1/27/2024) Where a study on metformin and cardiovascular disease fell short – and what it can teach us (1/20/2024) Targeting senescent cells for cognitive health (1/13/2024) The futility of estimating changes to all-cause mortality from target cancer screening studies (1/6/2024) Research Worth Sharing, December 2023 Edition (12/30/2023) Why is it so difficult to determine how nutrition impacts dementia risk? (12/16/2023) The MIND diet on trial: can diet choices impact cognitive health? (12/9/2023) Reassessing the relationship between alcohol intake and cardiovascular disease risk (12/2/2023) Continuous glucose monitoring to improve health in non-diabetics (11/25/2023) Do GLP-1 receptor agonists improve cardiovascular health independently of weight loss? (11/18/2023) How does APOE status impact the relationship between obesity and dementia risk? (11/11/2023) Understanding the Relationship Between Body Composition and Mortality Using Artificial Intelligence (AI) (11/4/2023) Is the frequency of menopausal symptoms an early barometer for later-in-life brain health? (10/28/2023) Could a psoriasis drug find new purpose in treating alcohol use disorder? (10/21/2023) Could an antihypertensive drug have independent benefits for longevity? (10/14/2023) Therapeutic potential and cardiovascular risks of medical cannabis (10/7/2023) Concerning findings on melatonin content in over-the-counter supplements (9/30/2023) The potential of probiotics in promoting female health (9/23/2023) Genetic similarities between unrelated look-alikes (9/16/2023) More than glycemic control: SGLT2 inhibitors may extend lung cancer survival (9/9/2023) Can a peptide found in bee stings offer hope for treatment-resistant breast cancers? (9/2/2023) Improving memory with transcranial neuromodulation (8/26/2023) Successful, early results using CAR T cells to treat an autoimmune disease (8/19/2023) How does aging increase risk of dehydration? (8/12/2023) Silencing the alarm on aspartame and cancer (8/5/2023) Can treating hearing loss improve cognitive trajectories and reduce dementia risk? (7/29/2023) First anti-inflammatory medication approved for treatment of ASCVD (7/22/2023) Ketamine-Assisted Therapy: A Promising Approach for Treating Depression and Anxiety? (7/15/2023) A case study on the importance of taking charge of one’s own health (7/8/2023) The Drive Turns Five (7/1/2023) Taurine improves the health and longevity of mice and monkeys – but what about humans? (6/24/2023) Cumulative time spent in “vigorous” physical activity lowers mortality risk (6/17/2023) Does carbohydrate load impact the balance between fat storage and oxidation? (6/10/2023) Separating substance from nonsense in a study on NMN supplements (6/3/2023) “The cholesterol paradox”: a catchy phrase for an idea with no substance (5/27/2023) Clearing the air on hormone replacement therapy (5/20/2023) Don’t drink and science: why a study on the cognitive effects of wine and cheese is sheer stupidity (5/13/2023) Supramaximal exercise transiently raises serum uric acid (5/6/2023) How failures in study selection can sink a meta-analysis (4/29/2023) Is a recent clinical trial enough to support the use of semaglutide in treating adolescent obesity? (4/22/2023) A new analysis of REDUCE-IT: benefits of omega-3s vs. harm from placebos (4/15/2023) Twenty Years of the Human Genome: Growing Older and Wiser (4/8/2023) Putting out the fire on the gas stove debate (4/1/2023) Can a new drug mimic the effects of exercise on bone and muscle? (3/25/2023) Finding the right fit in a psychotherapist (3/18/2023) A recent metformin study casts doubts on longevity indications (3/11/2023) More hype than substance: erythritol and cardiovascular risk (3/4/2023) How much control can we really have in studies on animals? (2/25/2023) Lean mass loss on GLP-1 receptor agonists: a downside of the “miracle drugs” (2/18/2023) Screen time and children’s cognition: a question of context (2/11/2023) The dangers of “healthy” addictions (2/4/2023) Twenty years after the Columbia disaster, what can we learn from the mistake of ignoring problems? (1/28/2023) To reduce appetite, skip late-night snacks (1/21/2023) Non-caffeine components of coffee and their effects on neurodegenerative diseases (1/14/2023) Antitumor mRNA vaccines are cause for optimism (1/7/2023) The Safety Debate Between Manual and Automatic Transmissions (12/31/2022) Understanding nature’s effects on stress requires more than intuition (12/17/2022) NR supplements: wasted money may not be the only risk with these questionable “anti-aging” drugs (12/10/2022) Book release date announcement (12/3/2022) Does solitude equate to loneliness? (11/26/2022) When it comes to medical advice, is less always more? (11/19/2022) Can an annual flu vaccine reduce your risk of Alzheimer’s disease? (11/12/2022) Reassuring new data on statin-induced Lp(a) elevation (11/5/2022) Modern Vampirism: “Young Blood” Transfusions (10/29/2022) Muscle Mass and Cognitive Function (10/22/2022) Confusion over results of a recent colonoscopy trial (10/15/2022) How horror may reduce anxiety and improve mental well-being (10/8/2022) The genetics of PCSK9i nonresponders (10/1/2022) A “miracle pill” for hangover prevention? (9/24/2022) The Epidemic on the Road (9/17/2022) Small steps toward improving research reliability (9/10/2022) Adding context to the Alzheimer’s disease research fraud charges (9/3/2022) Prioritizing “real friends” over “deal friends” (8/27/2022) Different effects of fat- vs. carbohydrate-restriction on neural reward signaling (8/20/2022) Vitamin D(éjà vu): new study, same old problems (8/13/2022) First Case of Human PCSK9 Gene-Editing (8/6/2022) Avoiding Injury Part II: Grip Strength (7/30/2022) Avoiding Injury Part I: Eccentric Strength (7/23/2022) And the 2050 World Cup champions are… robots? (7/16/2022) Cumulative effects of LDL-C reduction in mitigating cardiovascular risk (7/9/2022) The Drive podcast turns 4 (7/2/2022) Can cocoa help prevent cardiovascular death? (6/25/2022) A pilot immunotherapy trial is one step on a long road toward curing cancer (6/18/2022) Why do we lose muscle strength with age? (6/11/2022) Why do women have lower alcohol tolerance than men? (6/4/2022) Dangerous messaging around a recent SIDS study (5/28/2022) Do helmets give cyclists a false sense of security? (5/21/2022) For triglycerides, “normal” may not be “optimal” (5/14/2022) Are nitrates the next big thing for athletic performance? (5/7/2022) Does walking 10 minutes per day extend your life? (Hint: No.) (4/30/2022) Is cold exposure beneficial for metabolic health? (4/23/2022) Can a father’s metformin cause birth defects in his sons? (4/16/2022) How deadly is type 2 diabetes? (4/9/2022) Why a recent study hasn’t shaken my faith in statins (4/2/2022) Does PR Lotion really improve exercise performance? (3/26/2022) The Epidemic of Martiomania (3/19/2022) Are “safe” levels of air pollution really safe? (3/12/2022) A broader perspective on lung cancer (3/5/2022) Nutritional epidemiology: abolition vs defending the status quo (2/26/2022) A suicide safety net at the Golden Gate Bridge (2/19/2022) Hyperbolic discounting: friend and foe of goal achievement (2/12/2022) Low LDL cholesterol and neural development (2/5/2022) Not another COVID newsletter (1/29/2022) Why I’m for COVID vaccines, but against vaccine mandates. (1/23/2022) Are we oversimplifying Alzheimer’s disease? (1/15/2022) How do you move forward after making a fatal mistake? (1/8/2022) Is lab-grown meat the ‘meat of the future’? (1/2/2022) What a dead salmon can teach us about how we use machines (12/25/2021) How to Handle a Phishing Email (12/18/2021) Is lack of curiosity an age-related condition? (12/11/2021) Ketogenic Diets: Not For Everyone? (12/5/2021) Does Exercise Affect Lifespan? (11/28/2021) A Game Plan for Healthy Enjoyment of the Holidays (11/21/2021) How to Make Better Decisions: Understanding Bias vs. Noise (11/14/2021) Does fish oil cause cardiac arrhythmia in high-risk individuals? (11/7/2021) Does skipping breakfast increase the risk of an early death? Part II (10/31/2021) Does skipping breakfast increase the risk of an early death? Part I (10/24/2021) Ten errors in randomized experiments (10/17/2021) Is alternate-day fasting superior to calorie restriction for fat loss in lean adults? (10/10/2021) Morning vs evening exercise (10/3/2021) Does low cholesterol cause cognitive impairment? Part II (9/26/2021) Does low cholesterol cause cognitive impairment? Part I (9/19/2021) Rapamycin risks? (9/12/2021) The road to 9/11, and 20 years after (9/5/2021) Funding geroscience; suggested podcast listening (8/29/2021) How should we do drugs now?; searching for a Bob Ross painting (8/22/2021) Alternative perspectives on drug use and addiction (8/15/2021) What would you do if you won the lottery? (8/8/2021) How long can we live?; suggested listening (8/1/2021) A new frontier for early cancer detection? (7/25/2021) Rapamycin: one of my favorite stories; Ryan Lochte’s flip side on missing Olympic redemption (7/18/2021) Protecting against hearing loss (7/11/2021) Three years behind the podcast mic (7/4/2021) Brain implants and identity; recovering a fallen Marine’s Purple Heart (6/27/2021) Are continuous glucose monitors a waste of time for people without diabetes? (6/20/2021) A hope for treating Alzheimer’s disease? (6/13/2021) D-Day: June 6, 1944 (6/6/2021) MDMA for PTSD? (5/30/2021) Psilocybin for depression? (5/23/2021) How teeth sense cold; the efficacy of digital advertising (5/16/2021) Does NMN improve metabolic health in humans? (5/9/2021) Was COVID-19 the only culprit behind the extraordinary increase in deaths last year? (5/2/2021) What gives Rice Krispies their pop and my related experiment (4/25/2021) Cicada awakening (4/18/2021) mRNA vaccine technology (4/11/2021) Easter weekend egg boxing (4/4/2021) Metformin and COVID-19 mortality risk; a timeline of Kobe’s last day (3/28/2021) Commemorating Ayrton Senna’s birthday (3/21/2021) Early risk assessment markers to delay cardiovascular disease (3/14/2021) A scientific journal’s injustice; the true payoff of deliberate practice (3/7/2021) Promise and challenges for psilocybin and MDMA use in treatment (2/28/2021) A win for Topo Chico; COVID-19 vaccine second dose (2/21/2021) Should you get the COVID-19 vaccine? (2/14/2021) Lung cancer in never smokers; Diagnosing a medical case study (2/7/2021) Does vitamin D deficiency raise COVID-19 risk? (1/31/2021) The psychology of fact checking; A mother’s essay on her own sobriety (1/24/2021) Do I really need 8 glasses of water a day? (1/17/2021) Britain’s COVID-19 vaccine gamble; The upside of quitting (1/10/2021) More than a meme (1/3/2021) Psychedelic Santa; The dog that didn’t bark (12/27/2020) Should we still be worried about MSG? (12/20/2020) A few things worth checking out: 12-13-2020 (12/13/2020) Replacing sugar with allulose (12/6/2020) A few things worth sharing: 11-29-2020 (11/29/2020) Q&A on Alzheimer’s disease drug therapy with Dr. Richard Isaacson (11/22/2020) Masking emotion in the age of COVID-19 (11/15/2020) A few things worth sharing: 11-08-2020 (11/8/2020) Teaching science through the lens of discovery (11/1/2020) A few things worth sharing: 10-25-2020 (10/25/2020) Time-restricted eating: efficacy versus effectiveness (10/18/2020) Topo Chico (10/11/2020) A few things worth sharing: 10-04-2020 (10/4/2020) Colorectal cancer screening (9/27/2020) I need your help! (9/20/2020) A few things worth sharing: 09-13-2020 (9/13/2020) Randomized controlled trials: when the gold standard leaves you with fool’s gold (9/6/2020) A few things worth sharing: 08-30-2020 (8/30/2020) Normative errors and Surgisphere (8/23/2020) A few things worth sharing: 08-16-2020 (8/16/2020) Robin Williams (8/9/2020) The power of no (7/26/2020) How to find a good doctor (7/12/2020) Breakfast: a legacy of cereal…and sin? (6/28/2020) COVID framework: How does this thing end? (6/21/2020) SARS-CoV-2 and the host response: psychological stress (6/7/2020) The importance of red teams (5/24/2020) COVID-19: What’s wrong with the models? (4/20/2020) How to interpret screening tests: video, spreadsheet, and primer (4/14/2020) Multiple problems with a study linking proximity to major roads to dementia, Parkinson’s disease, Alzheimer’s disease, and MS (3/8/2020) The red meat and plant-based recommendation wars (3/1/2020) The pleasure of finding things out (2/23/2020) Alzheimer’s disease and glucose metabolism (2/16/2020) The killer(s) on the road: reducing your risk of automotive death (2/9/2020) Making sense of tragedy (2/2/2020) Nobel retractions (1/26/2020) Intermittent fasting (1/19/2020) My nutritional framework (1/12/2020) A new year (1/5/2020) Why is life expectancy in the US declining? (12/29/2019) Measuring cardiovascular disease risk and the importance of apoB (12/22/2019) Can fasting help athletes hold their breath longer? (12/8/2019) Book update (12/1/2019) Coronary artery calcium scan (11/24/2019) LDL-C & systolic blood pressure and lifetime risk of cardiovascular disease (11/10/2019) Is ditching meat a “game-changer” for your health? (11/3/2019) Is diet soda more dangerous than sugar-sweetened beverages? (10/20/2019) Metformin and exercise – déjà vu all over again? (10/13/2019) Am I fooling myself? (10/6/2019) Did a recent study show we can reverse aging? (9/29/2019) Hormone therapy and breast cancer? (9/22/2019) Can you reverse your biological age? (9/15/2019) Alternate Day Fasting (9/8/2019) Can you maintain muscle during fasting? (9/1/2019) Can you preserve lean body mass during “semi-starvation?” (8/25/2019) What can you prove? (8/18/2019) What if you never felt pain or anxiety? (8/11/2019) Fasting and cancer (8/4/2019) Cortisol and cross-pollination (7/28/2019) Conspiracy theory theories: July 20, 1969 (7/21/2019) Fast-breaking without glucose spiking (7/14/2019) Is there an optimal window of time-restricted feeding? (7/7/2019) European Vacation (6/30/2019) Metformin and exercise (6/23/2019) A hidden blockbuster drug for Alzheimer’s disease? (6/16/2019) Good docs (6/9/2019) Mind. Blown. (6/2/2019) The Sound of Silence (5/26/2019) Feeling entitled (5/19/2019) The Bad Science Behind ‘Skipping Breakfast’ (5/12/2019) You can win (5/5/2019) Targeting aging (4/28/2019) David Brooks and the quest for a moral life (4/21/2019) Trauma (4/14/2019) My view on wearables (4/7/2019) Driving while distracted (3/31/2019) Why am I such a knucklehead? (3/24/2019) How to fight suicide (3/17/2019) The mouse trap: lost in translation? (3/10/2019) Red meat, cancer, push-ups, and CVD (3/3/2019) Timely (2/24/2019) Ketones, fasting, and muscle loss (2/17/2019) Does Dad’s stress get passed along to his children? (2/10/2019) I’m suffering from the thought of suffering (2/3/2019) A radical new approach to Alzheimer’s? (1/27/2019) Wanna know what keeps me up at night? (1/20/2019) May I have your attention? (1/13/2019) Another name for madness (1/6/2019) Thinking in bets (12/30/2018) Predicting the future (12/23/2018) A new class of drugs to treat depression (12/16/2018) How to make better decisions (12/9/2018) Perspective and inspiration (12/2/2018) The art and science of screen time (11/25/2018) A moment of Zen and the importance of perspective (11/18/2018) The placebo effect (11/11/2018) Reading, resveratrol, and coffee (11/4/2018) Easter Island, inflammation, and ask me anything (10/28/2018) 1 in 10 people lack access to clean water (10/21/2018) A doctor with 1 million patients (10/14/2018) Statins, Lp(a), and upcoming podcast guests (10/7/2018) AMA, Alzheimer’s, podcast rec, and NAD rec (9/30/2018) Alzheimer’s prevention and the most important thing (9/30/2018) This Bud’s for you? Don’t mix alcohol with epidemiology (9/23/2018) Boston: Pearl Jam, Seyfried, Sinclair, and more (9/9/2018) The importance of sleep (9/2/2018) My visit to prison and is a “low-carb” diet going to shorten your life? (8/26/2018) Dunning, Kruger, and the opioid epidemic (8/19/2018) Salmon recipe (and mTOR) (8/12/2018) Robin Williams, Globalism on the brink, rapamycin and lifespan (8/5/2018) The Nothingburger and my favorite interview (7/29/2018) Fasting and conserving energy (7/22/2018) The keto buffet (7/15/2018) Living with Alzheimer’s (7/8/2018) Arrogance, humility, and the podcast launch (7/1/2018) Podcast is up! (6/24/2018) #00 – Sneak peek: The Peter Attia Drive (6/20/2018) Podcast, AMA, Lp(a), and Dr. Rosenrosen (6/17/2018) I don’t want to talk about it… (6/10/2018) Breaking2 (6/3/2018) Does it help to know your coronary artery calcium score? (5/27/2018) Comedy plus time… (5/20/2018) Simulators, treating depression, and management of T1D with diet (5/13/2018) MDMA and zero LDL-C (5/6/2018) The Joe Rogan Experience and exploring forgiveness (4/29/2018) Are you living for your résumé or your eulogy? (4/22/2018) Down the rabbit hole (4/15/2018) Narrative glossary: calorie restriction (4/15/2018) Studying studies … and Steve Largent (4/8/2018) Live podcast with Patrick O’Shaughnessy (4/2/2018) Remembering Ramanujan, Marvelous Marvin Hagler, and a new podcast (4/1/2018) Egg boxing (4/1/2018) 110 years of mortality: making progress? (3/25/2018) Calorie restriction? (3/18/2018) Calorie Restriction, Part I: What Does Restricting Calories Have to Do With Longevity? (3/12/2018) Sunday drive (3/11/2018) The importance of metabolic syndrome and the man behind it (3/4/2018) This is water (2/25/2018) Studying Studies: Part V – power and significance (2/19/2018) The Cosmos is all that is or ever was or ever will be… (2/18/2018) Fat, cancer, discomfort, and giving (2/11/2018) Lack of context may fuel spread of unintended consequences (2/7/2018) The power of second chances and the Super Bowl (2/4/2018) Studying Studies: Part IV – randomization and confounding (1/29/2018) Back to the future (1/28/2018) Is red meat killing us? (1/26/2018) Studying Studies: Part III – the motivation for observational studies (1/24/2018) Breaking the cycle of pain and shame (1/21/2018) Studying Studies: Part II – observational epidemiology (1/15/2018) A big predictor of heart disease risk that most doctors don’t screen for (1/14/2018) Why we’re not wired to think scientifically (and what can be done about it) (1/10/2018) Studying Studies: Part I – relative risk vs. absolute risk (1/8/2018) What I actually eat, part III (circa Q1 2014) (3/17/2014) Ketones and Carbohydrates: Can they co-exist? (8/26/2013) Is sugar toxic? (5/28/2013) Is a Mediterranean diet best for preventing heart disease? (2/27/2013) Ketosis – advantaged or misunderstood state? (Part II) (1/1/2013) Is a low fat diet best for weight loss? (12/18/2012) Hey Peter, what does your daughter eat? (8/23/2012) The interplay of exercise and ketosis – Part I (3/7/2012) Do calories matter? (2/29/2012) What are the side effects of aspartame, stevia, and other sugar substitutes? (2/8/2012) Is ketosis dangerous? (12/2/2011)