Family Medical History & Genetics - Peter Attia

#323 – CRISPR and the future of gene editing: scientific advances, genetic therapies, disease treatment potential, and ethical considerations | Feng Zhang, Ph.D.

Peter Attia — Mon, 28 Oct 2024 08:45:13 +0000

“One of the promises of gene editing is that it can provide a single treatment that is a cure for the disease.” —Feng Zhang

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Is Alzheimer’s disease unavoidable for individuals with a high-risk APOE genotype?

Peter Attia — Sat, 15 Jun 2024 11:00:18 +0000

A recent study reporting nearly 100% penetrance of the high-risk APOE-e4 variant is a lesson on the importance of unbiased sampling

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“DNA diets” are still a long way off from offering an easier route to weight loss

Peter Attia — Sat, 16 Mar 2024 11:00:53 +0000

A recent study reports that leveraging genetics to inform diet choice is ineffective in promoting weight loss beyond the effects of calorie restriction alone

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Genetic similarities between unrelated look-alikes

Peter Attia — Sat, 16 Sep 2023 11:00:26 +0000

With a world population of nearly 8 billion, there’s a good chance you have a doppelgänger, but might you share more than just appearances?

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#268 ‒ Genetics: testing, therapy, editing, association with disease risk, autism, and more | Wendy Chung, M.D., Ph.D.

Peter Attia — Mon, 28 Aug 2023 08:45:51 +0000

"There are literally tens of thousands of genetic variants in your genome, and what they mean and whether or not they do anything whatsoever is hard to know." —Wendy Chung

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#266 – AMA #50: Genetics: how they impact disease risk, what you can do about it, testing, and more

Peter Attia — Mon, 14 Aug 2023 08:45:24 +0000

“With how much uncertainty there is in genetic testing, I just think everybody needs to be thoughtful about it before they do it.” —Peter Attia

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Don’t drink and science: why a study on the cognitive effects of wine and cheese is sheer stupidity

Peter Attia — Sat, 13 May 2023 11:00:16 +0000

A study claiming that daily consumption of cheese and wine may improve long-term cognition seems more like a bad joke than reliable science.

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Twenty Years of the Human Genome: Growing Older and Wiser

Peter Attia — Sat, 08 Apr 2023 11:00:59 +0000

In the 20 years since the Human Genome Project was completed in 2003, we’ve dramatically expanded our understanding of the impact of genetics on human health, but the work is far from finished.

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The genetics of PCSK9i nonresponders

Peter Attia — Sat, 01 Oct 2022 11:00:43 +0000

A recent case study shines light on why some individuals are resistant to PCSK9 inhibitors.

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#222 ‒ How nutrition impacts longevity | Matt Kaeberlein, Ph.D.

Peter Attia — Mon, 12 Sep 2022 08:45:12 +0000

“It's really important that we be willing to change our beliefs about nutrition and other aspects of health as more data comes in.” —Matt Kaeberlein

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#212 – The neuroscience of obesity | Stephan Guyenet, Ph.D.

Peter Attia — Mon, 27 Jun 2022 08:45:27 +0000

“This system works better at protecting against fat loss than it does against fat gain.” —Stephan Guyenet

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Are there “biomarkers” for aging?

Peter Attia — Thu, 26 May 2022 14:48:40 +0000

This clip is from “Ask Me Anything” (AMA) episode #35, originally released on May 16, 2022. If you’re a member, you can now listen to this full episode on your private RSS feed or on our website. If you are not a member, learn more about the how to become a member and the benefits here.

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#207 – AMA #35: “Anti-Aging” Drugs — NAD+, metformin, & rapamycin

Peter Attia — Mon, 16 May 2022 08:45:28 +0000

“It's really hard to know, in my view, how important sirtuins are as longevity factors…If we accept that, then it's difficult to know [the importance of] activation of sirtuins by NAD as a longevity mechanism.” —Matt Kaeberlein

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Lessons from centenarians: why prevention of chronic disease is critical

Peter Attia — Tue, 26 Apr 2022 11:00:01 +0000

"To me, the takeaway for us, as physicians or people who want to have an extra five years of life or 10 years of life... is nothing matters more than prevention of chronic disease. And by the way, you don't get to prevent it once you have your heart attack. Secondary prevention is not prevention." - Peter Attia, M.D.

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#204 – Centenarians, metformin, and longevity | Nir Barzilai, M.D.

Peter Attia — Mon, 25 Apr 2022 08:45:21 +0000

“If you prevent aging and age-related disease, you're going to compress morbidity, too.” — Nir Barzilai

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Peter on the four horsemen of chronic disease

Peter Attia — Wed, 20 Apr 2022 11:00:26 +0000

This audio clip is from AMA #14: What lab tests can (and cannot) inform us about our overall objective of longevity, originally released on May 18, 2020. If you’re a subscriber, you can now listen to this full episode on your private RSS feed or on our website at the AMA #14 show notes page.…

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How useful are home DNA kits?

Peter Attia — Wed, 13 Apr 2022 11:00:46 +0000

This video clip is from AMA #8: DNA tests, longevity genes, metformin, fasting markers, salt, inflammation, and more, originally released on August 19, 2019.

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What is the role of genetics in determining one’s work ethic and success in a given discipline?

Peter Attia — Tue, 12 Apr 2022 23:00:39 +0000

This clip is from episode #183, James Clear: Building & Changing Habits, originally released on November 8, 2021.

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Peter on what to ask when gathering a family medical history

Peter Attia — Tue, 12 Apr 2022 11:00:46 +0000

This audio clip is from AMA #15: Real-world case studies, originally released on August 17, 2020.

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Peter on Alzheimer’s disease prevention and the latest on APOE4

Peter Attia — Tue, 12 Apr 2022 00:00:37 +0000

This clip is from episode #202, Peter on nutrition, disease prevention, sleep, and more, originally released on April 11, 2022.

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#196 – AMA #32: Exercise, squats, deadlifts, BFR, and TRT

Peter Attia — Mon, 21 Feb 2022 09:45:52 +0000

“You have to differentiate between signal and noise. . .it's easy to say testosterone causes heart disease just like it's easy to say estrogen causes breast cancer. But if you're actually going to go through all of the data. . .I think it becomes very difficult to make that case.” —Peter Attia

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Qualys #241 – The genetic gift of centenarians

Peter Attia — Tue, 18 Jan 2022 18:11:15 +0000

This episode of The Qualys is from podcast #35, Nir Barzilai, M.D.: How to tame aging, which was originally released on January 7, 2019.

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#184 – AMA #29: GLP-1 Agonists – The Future of Treating Obesity?

Peter Attia — Mon, 15 Nov 2021 09:45:56 +0000

“Getting deeper into how this drug works has certainly made me appreciate its power.” —Peter Attia

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#177 – Steven Rosenberg, M.D., Ph.D.: The development of cancer immunotherapy and its promise for treating advanced cancers

Peter Attia — Mon, 27 Sep 2021 08:45:51 +0000

“It's the balance of the aggressive immune reaction against the inhibitory molecules that can prevent that immune reaction that is the holy grail of trying to find effective treatments.” —Steven Rosenberg

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