Understanding and preventing metabolic disease | Peter Attia, M.D.

#338 ‒ Peter’s takeaways on aerobic exercise and VO2 max, insulin resistance, rising healthcare costs, treating children with autism and ADHD, and strength training | Quarterly Podcast Summary #4

Peter Attia — Mon, 03 Mar 2025 05:15:00 +0000

“You need to tackle the foe [type 2 diabetes] by addressing more than one leg of the stool at a time.” —Peter Attia

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#337 – Insulin resistance masterclass: The full body impact of metabolic dysfunction and prevention, diagnosis, and treatment | Ralph DeFronzo, M.D.

Peter Attia — Mon, 24 Feb 2025 05:15:00 +0000

“The pathophysiology will always tell you the truth.” —Ralph DeFronzo

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#336 – AMA #68: Fasting, well-balanced diets, alcohol, exercise for busy people, wearables, emotional health, assessing cardiovascular health, and more

Peter Attia — Mon, 17 Feb 2025 05:15:00 +0000

“It's the calorie restriction that provides the greatest benefit. How you go about achieving it is really a function of your style.” —Peter Attia

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#329 ‒ Special AMA: Peter on exercise, important labs, building good habits, promising longevity research, and more

Peter Attia — Mon, 16 Dec 2024 09:00:00 +0000

In this special episode of The Drive, Peter tackles a wide range of listener questions submitted over the past year. The discussion spans essential topics such as exercise—covering grip strength, traveling workouts, and why Peter doesn’t consider exercise an ideal weight-loss strategy—and the top biomarkers everyone should track. He also explores promising new longevity research,…

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#324 ‒ Metabolism, energy balance, and aging: How diet, calorie restriction, and macronutrients influence longevity and metabolic health | Eric Ravussin, Ph.D.

Peter Attia — Mon, 04 Nov 2024 09:45:31 +0000

“I still believe that a nutritional approach to weight loss without physical activity or exercise prescribed is not a good strategy. We should implement both and try to have people enjoying the exercise.” —Eric Ravussin

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#320 – AMA 64: New insights on GLP-1 agonists (Ozempic, Wegovy, Mounjaro) – efficacy, benefits, risks, and considerations in the rapidly evolving weight-loss drug landscape

Peter Attia — Mon, 07 Oct 2024 08:45:03 +0000

"If you're taking these drugs, really, really pay attention to your protein consumption and your resistance training. . .that's obviously going to be an important part of being on the right side of that body composition curve.” — Peter Attia

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Back on the merry-go-round of bad science regarding meat consumption

Peter Attia — Sat, 24 Aug 2024 11:00:01 +0000

A new observational study has reported positive associations between meat intake and type 2 diabetes risk, but let’s repeat: correlation is not causation.

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#314 ‒ Rethinking nutrition science: the evolving landscape of obesity treatment, GLP-1 agonists, protein, and the need for higher research standards | David Allison, Ph.D.

Peter Attia — Mon, 19 Aug 2024 08:45:11 +0000

“I think we really need a radically different public health paradigm.” —David Allison

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#311 ‒ Longevity 101: a foundational guide to Peter’s frameworks for longevity, and understanding CVD, cancer, neurodegenerative disease, nutrition, exercise, sleep, and more

Peter Attia — Mon, 29 Jul 2024 08:45:32 +0000

“I would say three-quarters of the benefits you can get towards a longer life, come solely from pursuing better health.” —Peter Attia

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#306 – AMA #60: preventing cognitive decline, nutrition myths, lowering blood glucose, apoB, and blood pressure, and more

Peter Attia — Mon, 17 Jun 2024 08:45:49 +0000

“Metabolic health, first and foremost, is the goal of nutrition.” —Peter Attia

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Do high protein diets increase cancer risk?

Peter Attia — Wed, 12 Jun 2024 14:00:00 +0000

Is there any merit to the idea that consuming more protein increases one’s risk of developing or dying from cancer?

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#302 – Confronting a metabolic epidemic: understanding liver health and how to prevent, diagnose, and manage MAFLD and liver disease | Julia Wattacheril, M.D., M.P.H.

Peter Attia — Mon, 20 May 2024 08:45:45 +0000

“The average person you're seeing with MASLD is much more at risk for cardiovascular-related outcomes and malignancy-related outcomes from their metabolic health than they are for liver-related risks.” —Julia Wattacheril

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#300 – Special episode: Peter on exercise, fasting, nutrition, stem cells, geroprotective drugs, and more — promising interventions or just noise?

Peter Attia — Mon, 06 May 2024 08:45:12 +0000

“The probability that having a high VO2 max, high muscle mass, and high muscle strength are going to increase the length of your life and improve the quality of your life. . .is so high that to act in disregard of that is irresponsible.” —Peter Attia

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Does the timing of sleep loss during the night impact subsequent negative metabolic effects?

Peter Attia — Sat, 27 Apr 2024 11:00:44 +0000

A recent study claims that late-night sleep loss is more damaging than early-night sleep loss, but the data leave ample room for doubt

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Does low iron intake change exercise capacity?

Peter Attia — Sat, 10 Feb 2024 12:00:45 +0000

A study demonstrates metabolic shifts that occur with and without sufficient iron levels

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#283 ‒ Gut health & the microbiome: improving and maintaining the microbiome, probiotics, prebiotics, innovative treatments, and more | Colleen Cutcliffe, Ph.D.

Peter Attia — Mon, 18 Dec 2023 09:45:06 +0000

“You start out almost like a blank slate, you get a lot more diverse, and then as we age, you start to lose that diversity and therefore some key functions in the microbiome.” —Colleen Cutcliffe

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#279 – AMA #53: Metabolic health & pharmacologic interventions: SGLT-2 inhibitors, metformin, GLP-1 agonists, and the impact of statins

Peter Attia — Mon, 13 Nov 2023 09:45:23 +0000

“It is worth noting, and this is a very important question, that it does not appear that the effect of statins on insulin resistance is a function of lipids being lowered.” —Peter Attia

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#271 – AMA #51: Understanding and improving your metabolic health

Peter Attia — Mon, 18 Sep 2023 08:45:10 +0000

“Zone 2 output is arguably the most important functional test we have of metabolic health.” —Peter Attia

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#252 ‒ Latest insights on Alzheimer’s disease, cancer, exercise, nutrition, and fasting | Rhonda Patrick, Ph.D.

Peter Attia — Mon, 01 May 2023 08:45:03 +0000

“My perspective has shifted as any scientist that's following data should… When new data comes out, you have to reassess things.” —Rhonda Patrick

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Is a recent clinical trial enough to support the use of semaglutide in treating adolescent obesity?

Peter Attia — Sat, 22 Apr 2023 11:00:52 +0000

The imperative for effective weight management strategies in children and teens is clear, but in our desperation for effective obesity treatments, are we allowing ourselves to be too shortsighted on testing?

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The five main tools for managing blood glucose numbers

Peter Attia — Tue, 16 Aug 2022 13:00:17 +0000

This clip is from AMA #26: Continuous glucose monitors, zone 2 training, and a framework for interventions, originally released on August 23, 2021.

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#216 – Metabolomics, NAD+, and cancer metabolism | Josh Rabinowitz, M.D., Ph.D.

Peter Attia — Mon, 01 Aug 2022 08:45:08 +0000

"My big hope is that we're going to be able to have some combination of directed, metabolic immune supplements and diet that really work with therapy to treat cancer.” —Josh Rabinowitz

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#215 – The gut-brain connection | Michael Gershon, M.D.

Peter Attia — Mon, 25 Jul 2022 08:45:05 +0000

“The reason I call it “The Second Brain” is that, like the brain in the head, the nervous system of the gut is able to function and control reflexes and behavior independently of any influence from the brain or spinal cord.” —Michael Gershon

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Sugar & Cancer: Does Fructose Cause Cancer?

Peter Attia — Fri, 24 Jun 2022 19:41:48 +0000

This clip is from episode #187 – Sam Apple: The Warburg Effect—Otto Warburg’s cancer metabolism theory, originally released on December 13, 2021.

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