Cognitive Health & Neurodegenerative Disease Prevention - Peter Attia

#336 – AMA #68: Fasting, well-balanced diets, alcohol, exercise for busy people, wearables, emotional health, assessing cardiovascular health, and more

Peter Attia — Mon, 17 Feb 2025 05:15:00 +0000

“It's the calorie restriction that provides the greatest benefit. How you go about achieving it is really a function of your style.” —Peter Attia

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#334 – Cardiovascular disease, the number one killer: development, biomarkers, apoB, cholesterol, brain health, and more | Tom Dayspring, M.D.

Peter Attia — Mon, 03 Feb 2025 05:15:00 +0000

“Cholesterol is almost certainly the most important molecule in the brain.” —Tom Dayspring

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A link between antihypertensive medications and fall risk reminds us to take precautions

Peter Attia — Sat, 11 Jan 2025 12:00:00 +0000

A recent study highlights the association between blood pressure medications and risk of falls and fall-related injuries, but we can take steps to offset the danger

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#329 ‒ Special AMA: Peter on exercise, important labs, building good habits, promising longevity research, and more

Peter Attia — Mon, 16 Dec 2024 09:00:00 +0000

In this special episode of The Drive, Peter tackles a wide range of listener questions submitted over the past year. The discussion spans essential topics such as exercise—covering grip strength, traveling workouts, and why Peter doesn’t consider exercise an ideal weight-loss strategy—and the top biomarkers everyone should track. He also explores promising new longevity research,…

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Shingles and brain health: an emerging link or healthy user bias?

Peter Attia — Sat, 23 Nov 2024 12:00:00 +0000

Several research articles have been circulating in the news, prompting excitement about the supposed ability of the shingles vaccine to prevent cognitive decline, but is there a causal link?

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#323 – CRISPR and the future of gene editing: scientific advances, genetic therapies, disease treatment potential, and ethical considerations | Feng Zhang, Ph.D.

Peter Attia — Mon, 28 Oct 2024 08:45:13 +0000

“One of the promises of gene editing is that it can provide a single treatment that is a cure for the disease.” —Feng Zhang

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High-intensity interval training and cognitive function in older adults: promising but limited findings

Peter Attia — Sat, 28 Sep 2024 11:00:56 +0000

A new study indicates that HIIT may help delay or even reverse age-related declines in memory and learning, but this exercise modality remains just one aspect of a well-balanced regimen.

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#313 – AMA #62: Protein’s impact on appetite and weight management, and uric acid’s link to disease and how to manage levels

Peter Attia — Mon, 12 Aug 2024 08:45:11 +0000

"The body responds in pretty significant ways to alterations in protein availability.” —Peter Attia

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#311 ‒ Longevity 101: a foundational guide to Peter’s frameworks for longevity, and understanding CVD, cancer, neurodegenerative disease, nutrition, exercise, sleep, and more

Peter Attia — Mon, 29 Jul 2024 08:45:32 +0000

“I would say three-quarters of the benefits you can get towards a longer life, come solely from pursuing better health.” —Peter Attia

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Don’t underestimate the importance of oral health

Peter Attia — Sat, 20 Jul 2024 11:00:21 +0000

A meta-analysis reports that toothbrushing reduced the risk of hospital-acquired pneumonia among ICU patients, hinting at the whole-body impacts of oral hygiene

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Does hormone replacement therapy impact dementia risk?

Peter Attia — Sat, 29 Jun 2024 11:00:13 +0000

A recent case-control study reports that menopausal hormone therapy is associated with increased risk of dementia, but results have little relevance for modern clinical practice

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#306 – AMA #60: preventing cognitive decline, nutrition myths, lowering blood glucose, apoB, and blood pressure, and more

Peter Attia — Mon, 17 Jun 2024 08:45:49 +0000

“Metabolic health, first and foremost, is the goal of nutrition.” —Peter Attia

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Is Alzheimer’s disease unavoidable for individuals with a high-risk APOE genotype?

Peter Attia — Sat, 15 Jun 2024 11:00:18 +0000

A recent study reporting nearly 100% penetrance of the high-risk APOE-e4 variant is a lesson on the importance of unbiased sampling

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#303 – A breakthrough in Alzheimer’s disease: the promising potential of klotho for brain health, cognitive decline, and as a therapeutic tool for Alzheimer’s disease | Dena Dubal, M.D., Ph.D.

Peter Attia — Mon, 27 May 2024 08:45:09 +0000

“I have this dream that people might be able someday to benefit from klotho, this factor that naturally circulates in our body, that helps with longevity, that helps with other organ systems and enhances the brain.” —Dena Dubal

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#300 – Special episode: Peter on exercise, fasting, nutrition, stem cells, geroprotective drugs, and more — promising interventions or just noise?

Peter Attia — Mon, 06 May 2024 08:45:12 +0000

“The probability that having a high VO2 max, high muscle mass, and high muscle strength are going to increase the length of your life and improve the quality of your life. . .is so high that to act in disregard of that is irresponsible.” —Peter Attia

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Aerobic exercise for Parkinson’s disease

Peter Attia — Sat, 02 Mar 2024 12:00:35 +0000

The neuroprotective nature of aerobic exercise influences a variety of Parkinson’s disease symptoms, on top of its role in impacting disease risk and progression

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Targeting senescent cells for cognitive health

Peter Attia — Sat, 13 Jan 2024 12:00:33 +0000

With the recent publication of the first clinical trial of senolytics for AD treatment, popular interest in these drugs has swelled, but is the excitement justified?

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Why is it so difficult to determine how nutrition impacts dementia risk?

Peter Attia — Sat, 16 Dec 2023 12:00:33 +0000

When it comes to nutrition research, neither observational nor interventional studies have been able to tell the full story. A report by the Nutrition for Dementia Prevention Working Group offers ideas for improving both.

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The MIND diet on trial: can diet choices impact cognitive health?

Peter Attia — Sat, 09 Dec 2023 12:00:13 +0000

The results were lackluster, but a closer look leaves room for other explanations

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How does APOE status impact the relationship between obesity and dementia risk?

Peter Attia — Sat, 11 Nov 2023 12:00:39 +0000

Obesity has been reported by some to increase risk of dementia, while other studies have reported that obesity is protective against dementia. Might the effects of APOE genotype help to explain the discrepancy?

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Is the frequency of menopausal symptoms an early barometer for later-in-life brain health?

Peter Attia — Sat, 28 Oct 2023 11:00:37 +0000

More than “bothersome”: Frequent menopausal hot flashes during sleep are associated with greater white matter hyperintensity volume

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Improving memory with transcranial neuromodulation

Peter Attia — Sat, 26 Aug 2023 11:00:00 +0000

Research shows that noninvasive neuromodulation can improve performance in memory tasks. Is this technique simply a research tool, or is it a therapy of the future?

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Can treating hearing loss improve cognitive trajectories and reduce dementia risk?

Peter Attia — Sat, 29 Jul 2023 11:00:34 +0000

Age-related hearing loss is very common and has long been known to correlate strongly with cognitive decline. A just-published randomized trial sought to evaluate causality in this association. What do we know now?

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#263 ‒ Concussions and head trauma: symptoms, treatment, and recovery | Micky Collins, Ph.D.

Peter Attia — Mon, 24 Jul 2023 08:45:16 +0000

“If you bring me a patient with concussion, I can pretty much tell you I can get that patient better. There are highly effective treatments with this injury.” —Micky Collins

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