Medications Archives - Peter Attia

Metformin as a potential longevity medication: where do we stand?

Peter Attia — Wed, 26 Feb 2025 13:00:00 +0000

Hype over metformin’s longevity effects has waxed and waned, with a recent boost from a high-profile study. How should we think about this evidence?

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#337 – Insulin resistance masterclass: The full body impact of metabolic dysfunction and prevention, diagnosis, and treatment | Ralph DeFronzo, M.D.

Peter Attia — Mon, 24 Feb 2025 05:15:00 +0000

“The pathophysiology will always tell you the truth.” —Ralph DeFronzo

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A common nasal decongestant appears to be ineffective, so what alternatives exist?

Peter Attia — Sat, 22 Feb 2025 12:00:00 +0000

Despite a long history of use for decongestion, oral phenylephrine may soon disappear from cold and allergy medications due to a lack of efficacy.

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How can the process of drug development be improved?

Peter Attia — Sat, 15 Feb 2025 12:00:00 +0000

Insights as to why so many drug candidates fail to make it through the development pipeline, and how certain strategies might help

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A link between antihypertensive medications and fall risk reminds us to take precautions

Peter Attia — Sat, 11 Jan 2025 12:00:00 +0000

A recent study highlights the association between blood pressure medications and risk of falls and fall-related injuries, but we can take steps to offset the danger

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#329 ‒ Special AMA: Peter on exercise, important labs, building good habits, promising longevity research, and more

Peter Attia — Mon, 16 Dec 2024 09:00:00 +0000

In this special episode of The Drive, Peter tackles a wide range of listener questions submitted over the past year. The discussion spans essential topics such as exercise—covering grip strength, traveling workouts, and why Peter doesn’t consider exercise an ideal weight-loss strategy—and the top biomarkers everyone should track. He also explores promising new longevity research,…

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Evaluating NAD and NAD precursors for health and longevity

Peter Attia — Wed, 11 Dec 2024 23:07:16 +0000

NAD and its precursors – mainly NR and NMN – have garnered attention for numerous purported benefits, but which are supported by evidence?

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#324 ‒ Metabolism, energy balance, and aging: How diet, calorie restriction, and macronutrients influence longevity and metabolic health | Eric Ravussin, Ph.D.

Peter Attia — Mon, 04 Nov 2024 09:45:31 +0000

“I still believe that a nutritional approach to weight loss without physical activity or exercise prescribed is not a good strategy. We should implement both and try to have people enjoying the exercise.” —Eric Ravussin

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Failure of resveratrol to improve metabolic health is another nail in the coffin for the alleged “anti-aging” compound

Peter Attia — Sat, 26 Oct 2024 11:00:12 +0000

A recent meta-analysis of randomized trials assessed the performance of resveratrol in improving various metrics of metabolic health

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#322 – Bone health for life: building strong bones, preventing age-related loss, and reversing osteoporosis with evidence-based exercise | Belinda Beck, Ph.D.

Peter Attia — Mon, 21 Oct 2024 08:45:51 +0000

“Bone is a ‘use it or lose it’ tissue.” —Belinda Beck

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Beyond the headlines: evaluating exercise as an equivalent to medication for the treatment of depression and anxiety

Peter Attia — Sat, 19 Oct 2024 11:00:52 +0000

Popular media has circulated news of a study allegedly showing that exercise is preferable to medication as a treatment for anxiety and depression, but is this interpretation justified?

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#320 – AMA 64: New insights on GLP-1 agonists (Ozempic, Wegovy, Mounjaro) – efficacy, benefits, risks, and considerations in the rapidly evolving weight-loss drug landscape

Peter Attia — Mon, 07 Oct 2024 08:45:03 +0000

"If you're taking these drugs, really, really pay attention to your protein consumption and your resistance training. . .that's obviously going to be an important part of being on the right side of that body composition curve.” — Peter Attia

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#314 ‒ Rethinking nutrition science: the evolving landscape of obesity treatment, GLP-1 agonists, protein, and the need for higher research standards | David Allison, Ph.D.

Peter Attia — Mon, 19 Aug 2024 08:45:11 +0000

“I think we really need a radically different public health paradigm.” —David Allison

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#311 ‒ Longevity 101: a foundational guide to Peter’s frameworks for longevity, and understanding CVD, cancer, neurodegenerative disease, nutrition, exercise, sleep, and more

Peter Attia — Mon, 29 Jul 2024 08:45:32 +0000

“I would say three-quarters of the benefits you can get towards a longer life, come solely from pursuing better health.” —Peter Attia

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#300 – Special episode: Peter on exercise, fasting, nutrition, stem cells, geroprotective drugs, and more — promising interventions or just noise?

Peter Attia — Mon, 06 May 2024 08:45:12 +0000

“The probability that having a high VO2 max, high muscle mass, and high muscle strength are going to increase the length of your life and improve the quality of your life. . .is so high that to act in disregard of that is irresponsible.” —Peter Attia

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#291 ‒ The role of testosterone in males and females, performance-enhancing drugs, sustainable fat loss, supplements, and more | Derek, More Plates More Dates Pt.2

Peter Attia — Mon, 26 Feb 2024 09:45:03 +0000

“These things can all move the needle [on testosterone] like 100+ ng/dL potentially, depending on how deficient you are. So some of these are low hanging fruits with the sleep, micronutrients, minerals, actual macro intake.” —Derek, More Plates More Dates

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Does low iron intake change exercise capacity?

Peter Attia — Sat, 10 Feb 2024 12:00:45 +0000

A study demonstrates metabolic shifts that occur with and without sufficient iron levels

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Where a study on metformin and cardiovascular disease fell short – and what it can teach us

Peter Attia — Sat, 20 Jan 2024 12:00:14 +0000

An investigation on metformin, diabetes, lipid biology, and cardiovascular disease offered little insight on any of these topics, but it illustrates common problems in scientific research

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#281 ‒ Longevity drugs, aging biomarkers, and updated findings from the Interventions Testing Program (ITP) | Rich Miller, M.D., Ph.D.

Peter Attia — Mon, 04 Dec 2023 09:45:47 +0000

“What we try to do is quite simple. We try to find drugs that will slow aging and extend mouse lifespan.” —Rich Miller

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Do GLP-1 receptor agonists improve cardiovascular health independently of weight loss?

Peter Attia — Sat, 18 Nov 2023 12:00:18 +0000

A new trial has reported that the GLP-1 receptor agonist semaglutide reduces risk of cardiovascular events in patients with obesity – but that’s not the question we ought to be asking.

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#274 – Performance-enhancing drugs and hormones: risks, rewards, and broader implications for the public | Derek: More Plates, More Dates

Peter Attia — Mon, 09 Oct 2023 08:45:41 +0000

“There's no drug that's purely selective exactly where you want and it's perfect.” —Derek - More Plates More Dates

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#272 ‒ Rapamycin: potential longevity benefits, surge in popularity, unanswered questions, and more | David Sabatini, M.D., Ph.D. and Matt Kaeberlein, Ph.D.

Peter Attia — Mon, 25 Sep 2023 08:45:33 +0000

"[Rapamycin] is the most robust and reproducible drug that we know about today for impacting not only longevity, but to the extent that we can measure various metrics of healthspan in complex animals, rapamycin also seems to positively impact pretty much every aspect of health span that we measure.” —Matt Kaeberlein

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Ketamine-Assisted Therapy: A Promising Approach for Treating Depression and Anxiety?

Peter Attia — Sat, 15 Jul 2023 11:00:53 +0000

A recent study investigated the safety and effectiveness of at-home ketamine-assisted therapy for the treatment of depression and anxiety.

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#256 ‒ The endocrine system: exploring thyroid, adrenal, and sex hormones | Peter Attia, M.D.

Peter Attia — Mon, 29 May 2023 08:45:44 +0000

In this special episode of The Drive, Peter provides a comprehensive overview of the various endocrine systems: the thyroid system, the adrenal system, and the sex hormone system (for both men and women). He walks through the basic biology and the feedback cycles that regulate the production of these hormones and discusses the various options…

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