Medications & supplements Archives - Peter Attia

Metformin as a potential longevity medication: where do we stand?

Peter Attia — Wed, 26 Feb 2025 13:00:00 +0000

Hype over metformin’s longevity effects has waxed and waned, with a recent boost from a high-profile study. How should we think about this evidence?

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#337 – Insulin resistance masterclass: The full body impact of metabolic dysfunction and prevention, diagnosis, and treatment | Ralph DeFronzo, M.D.

Peter Attia — Mon, 24 Feb 2025 05:15:00 +0000

“The pathophysiology will always tell you the truth.” —Ralph DeFronzo

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A common nasal decongestant appears to be ineffective, so what alternatives exist?

Peter Attia — Sat, 22 Feb 2025 12:00:00 +0000

Despite a long history of use for decongestion, oral phenylephrine may soon disappear from cold and allergy medications due to a lack of efficacy.

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How can the process of drug development be improved?

Peter Attia — Sat, 15 Feb 2025 12:00:00 +0000

Insights as to why so many drug candidates fail to make it through the development pipeline, and how certain strategies might help

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Unlocking the potential of migraine medications for endometriosis treatment

Peter Attia — Sat, 01 Feb 2025 12:00:00 +0000

Recent mouse studies indicate that FDA-approved CGRP blockers might offer a new treatment option for a condition affecting millions

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#331 ‒ Optimizing endurance performance: metrics, nutrition, lactate, and more insights from elite performers | Olav Aleksander Bu (Pt. 2)

Peter Attia — Mon, 13 Jan 2025 05:15:00 +0000

“Sometimes it makes it more universally easy to understand if we think of what kind of sport we do as a function of intensity and duration.” —Olav Aleksander Bu

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A link between antihypertensive medications and fall risk reminds us to take precautions

Peter Attia — Sat, 11 Jan 2025 12:00:00 +0000

A recent study highlights the association between blood pressure medications and risk of falls and fall-related injuries, but we can take steps to offset the danger

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#329 ‒ Special AMA: Peter on exercise, important labs, building good habits, promising longevity research, and more

Peter Attia — Mon, 16 Dec 2024 09:00:00 +0000

In this special episode of The Drive, Peter tackles a wide range of listener questions submitted over the past year. The discussion spans essential topics such as exercise—covering grip strength, traveling workouts, and why Peter doesn’t consider exercise an ideal weight-loss strategy—and the top biomarkers everyone should track. He also explores promising new longevity research,…

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Evaluating NAD and NAD precursors for health and longevity

Peter Attia — Wed, 11 Dec 2024 23:07:16 +0000

NAD and its precursors – mainly NR and NMN – have garnered attention for numerous purported benefits, but which are supported by evidence?

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#324 ‒ Metabolism, energy balance, and aging: How diet, calorie restriction, and macronutrients influence longevity and metabolic health | Eric Ravussin, Ph.D.

Peter Attia — Mon, 04 Nov 2024 09:45:31 +0000

“I still believe that a nutritional approach to weight loss without physical activity or exercise prescribed is not a good strategy. We should implement both and try to have people enjoying the exercise.” —Eric Ravussin

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Failure of resveratrol to improve metabolic health is another nail in the coffin for the alleged “anti-aging” compound

Peter Attia — Sat, 26 Oct 2024 11:00:12 +0000

A recent meta-analysis of randomized trials assessed the performance of resveratrol in improving various metrics of metabolic health

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#322 – Bone health for life: building strong bones, preventing age-related loss, and reversing osteoporosis with evidence-based exercise | Belinda Beck, Ph.D.

Peter Attia — Mon, 21 Oct 2024 08:45:51 +0000

“Bone is a ‘use it or lose it’ tissue.” —Belinda Beck

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Beyond the headlines: evaluating exercise as an equivalent to medication for the treatment of depression and anxiety

Peter Attia — Sat, 19 Oct 2024 11:00:52 +0000

Popular media has circulated news of a study allegedly showing that exercise is preferable to medication as a treatment for anxiety and depression, but is this interpretation justified?

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#320 – AMA 64: New insights on GLP-1 agonists (Ozempic, Wegovy, Mounjaro) – efficacy, benefits, risks, and considerations in the rapidly evolving weight-loss drug landscape

Peter Attia — Mon, 07 Oct 2024 08:45:03 +0000

"If you're taking these drugs, really, really pay attention to your protein consumption and your resistance training. . .that's obviously going to be an important part of being on the right side of that body composition curve.” — Peter Attia

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#316 – AMA #63: A guide for hair loss: causes, treatments, transplants, and sex-specific considerations

Peter Attia — Mon, 09 Sep 2024 08:45:36 +0000

“Genetic sensitivity to DHT appears far more important than absolute DHT level. But. . .lowering DHT is a very important strategy to either preventing or halting hair loss.” —Peter Attia

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#314 ‒ Rethinking nutrition science: the evolving landscape of obesity treatment, GLP-1 agonists, protein, and the need for higher research standards | David Allison, Ph.D.

Peter Attia — Mon, 19 Aug 2024 08:45:11 +0000

“I think we really need a radically different public health paradigm.” —David Allison

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A recent study does little to supplement earlier knowledge on multivitamins and health

Peter Attia — Sat, 10 Aug 2024 11:00:01 +0000

Mainstream media has reported dubious results of a study indicating that the use of multivitamins is not associated with a reduction in mortality risk, but even if this were true, does it really mean they offer no benefit for health?

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#311 ‒ Longevity 101: a foundational guide to Peter’s frameworks for longevity, and understanding CVD, cancer, neurodegenerative disease, nutrition, exercise, sleep, and more

Peter Attia — Mon, 29 Jul 2024 08:45:32 +0000

“I would say three-quarters of the benefits you can get towards a longer life, come solely from pursuing better health.” —Peter Attia

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Does pharmacological treatment for ADHD increase risk of cardiovascular disease?

Peter Attia — Sat, 27 Jul 2024 11:00:00 +0000

A recent study suggests that use of medications commonly prescribed for ADHD treatment is associated with increased risk of certain cardiovascular conditions, but does it exceed the risks associated with untreated ADHD?

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Does hormone replacement therapy impact dementia risk?

Peter Attia — Sat, 29 Jun 2024 11:00:13 +0000

A recent case-control study reports that menopausal hormone therapy is associated with increased risk of dementia, but results have little relevance for modern clinical practice

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#306 – AMA #60: preventing cognitive decline, nutrition myths, lowering blood glucose, apoB, and blood pressure, and more

Peter Attia — Mon, 17 Jun 2024 08:45:49 +0000

“Metabolic health, first and foremost, is the goal of nutrition.” —Peter Attia

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#304 – NEW: Introducing quarterly podcast summaries – Peter shares his biggest takeaways on muscle protein synthesis, VO2 max, toe strength, gut health, and more

Peter Attia — Mon, 03 Jun 2024 08:45:16 +0000

“Getting a high VO2 max and being very strong are very hard to do. They take a long time. Everybody can do them, but they can't be done quickly and easily, so therefore, they are the tip of the spear.” —Peter Attia

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Oldies-But-Goodies, May 2024 Edition

Peter Attia — Sat, 25 May 2024 11:00:26 +0000

A collection of past newsletters on topics including continuous glucose monitors, fish oil, nutritional epidemiology, fostering meaningful friendships, and traffic safety

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#300 – Special episode: Peter on exercise, fasting, nutrition, stem cells, geroprotective drugs, and more — promising interventions or just noise?

Peter Attia — Mon, 06 May 2024 08:45:12 +0000

“The probability that having a high VO2 max, high muscle mass, and high muscle strength are going to increase the length of your life and improve the quality of your life. . .is so high that to act in disregard of that is irresponsible.” —Peter Attia

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