Genes - APOE4 Archives - Peter Attia

Is Alzheimer’s disease unavoidable for individuals with a high-risk APOE genotype?

Peter Attia — Sat, 15 Jun 2024 11:00:18 +0000

A recent study reporting nearly 100% penetrance of the high-risk APOE-e4 variant is a lesson on the importance of unbiased sampling

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#303 – A breakthrough in Alzheimer’s disease: the promising potential of klotho for brain health, cognitive decline, and as a therapeutic tool for Alzheimer’s disease | Dena Dubal, M.D., Ph.D.

Peter Attia — Mon, 27 May 2024 08:45:09 +0000

“I have this dream that people might be able someday to benefit from klotho, this factor that naturally circulates in our body, that helps with longevity, that helps with other organ systems and enhances the brain.” —Dena Dubal

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How does APOE status impact the relationship between obesity and dementia risk?

Peter Attia — Sat, 11 Nov 2023 12:00:39 +0000

Obesity has been reported by some to increase risk of dementia, while other studies have reported that obesity is protective against dementia. Might the effects of APOE genotype help to explain the discrepancy?

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#266 – AMA #50: Genetics: how they impact disease risk, what you can do about it, testing, and more

Peter Attia — Mon, 14 Aug 2023 08:45:24 +0000

“With how much uncertainty there is in genetic testing, I just think everybody needs to be thoughtful about it before they do it.” —Peter Attia

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#263 ‒ Concussions and head trauma: symptoms, treatment, and recovery | Micky Collins, Ph.D.

Peter Attia — Mon, 24 Jul 2023 08:45:16 +0000

“If you bring me a patient with concussion, I can pretty much tell you I can get that patient better. There are highly effective treatments with this injury.” —Micky Collins

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#255 ‒ Latest therapeutics in CVD, APOE’s role in Alzheimer’s disease and CVD, familial hypercholesterolemia, and more | John Kastelein, M.D., Ph.D.

Peter Attia — Mon, 22 May 2023 08:45:50 +0000

“One of the things that is so dangerous about this disorder is that the plaque that you get in FH is a soft plaque.” —John Kastelein

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Don’t drink and science: why a study on the cognitive effects of wine and cheese is sheer stupidity

Peter Attia — Sat, 13 May 2023 11:00:16 +0000

A study claiming that daily consumption of cheese and wine may improve long-term cognition seems more like a bad joke than reliable science.

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#251 – AMA #46: Optimizing brain health: Alzheimer’s disease risk factors, APOE, prevention strategies, and more

Peter Attia — Mon, 17 Apr 2023 08:45:56 +0000

“The bottom line here is the earlier you were diagnosed with type 2 diabetes, the higher your risk of dementia.” —Peter Attia

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Heart Disease: Labs & Diagnostic Tests

Peter Attia — Tue, 30 Aug 2022 12:00:26 +0000

This video clip is from episode #203 — AMA #34: What causes heart disease? — originally released on April 18, 2022. If you’re not a subscriber and listening on a podcast player, you’ll only be able to hear a preview of the AMA. If you’re a subscriber, you can now listen to this full episode…

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Why does Alzheimer’s disease affect more women than men?

Peter Attia — Wed, 27 Jul 2022 13:00:26 +0000

This clip is from episode #138 – Lauren Miller Rogen and Richard Isaacson, M.D.: Alzheimer’s disease prevention—patient and doctor perspectives, originally released on November 23, 2020.

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#204 – Centenarians, metformin, and longevity | Nir Barzilai, M.D.

Peter Attia — Mon, 25 Apr 2022 08:45:21 +0000

“If you prevent aging and age-related disease, you're going to compress morbidity, too.” — Nir Barzilai

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#203 – AMA #34: What Causes Heart Disease?

Peter Attia — Mon, 18 Apr 2022 08:45:38 +0000

“Not everybody dies from atherosclerosis, but… everybody dies with it.” — Peter Attia

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Peter on Alzheimer’s disease prevention and the latest on APOE4

Peter Attia — Tue, 12 Apr 2022 00:00:37 +0000

This clip is from episode #202, Peter on nutrition, disease prevention, sleep, and more, originally released on April 11, 2022.

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#202 – Peter on nutrition, disease prevention, sleep, and more — looking back on the last 100 episodes

Peter Attia — Mon, 11 Apr 2022 08:45:15 +0000

“I really think that in 10 years we're going to basically be using designer-based immunotherapies to eradicate most solid organ metastatic cancers.” —Peter Attia

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Does low cholesterol cause cognitive impairment? Part II

Peter Attia — Sun, 26 Sep 2021 09:45:11 +0000

Safety of lipid-lowering therapy

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#164 – Amanda Smith, M.D.: Diagnosing, preventing, and treating Alzheimer’s disease, and what we can all learn from patients with dementia

Peter Attia — Mon, 07 Jun 2021 08:45:21 +0000

“At the end of the day, it really has to do with how people see themselves, how people interact with the world, what kind of relationships they have, how able they are to let go of things that they've lost and how able they are to focus on the positive.” —Amanda Smith

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#147 – Hussein Yassine, M.D.: Deep dive into the “Alzheimer’s gene” (APOE), brain health, and omega-3s

Peter Attia — Mon, 01 Feb 2021 10:45:23 +0000

“What's important is in science, you always have to be skeptical and you always need to find whether any particular study can be replicated or not before you make strong recommendations and adopt any drastic change and how you are consuming certain things, whether it's a medication or a diet or a supplement.” — Hussein Yassine, M.D.

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#138 – Lauren Miller Rogen and Richard Isaacson, M.D.: Alzheimer’s disease prevention—patient and doctor perspectives

Peter Attia — Mon, 23 Nov 2020 10:45:08 +0000

“Believe it or not, there are 46 million Americans with Alzheimer’s disease in their brain right now, but no symptoms.” — Richard Isaacson

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#120 – AMA with Dom D’Agostino, Ph.D., Part II of II: Ketosis for cancer and chronic disease, hyperbaric oxygen therapy, and the effect of ketosis on female health

Peter Attia — Mon, 20 Jul 2020 09:45:22 +0000

"The function of the mitochondria and mitochondrial health are the ultimate mitigator of neurodegenerative diseases...just by reducing the potential for reactive oxygen species related damage." — Dom D’Agostino

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#116 – AMA with Dom D’Agostino, Ph.D., Part I of II: Ketogenic diet, exogenous ketones, and exercise

Peter Attia — Mon, 22 Jun 2020 09:45:12 +0000

"If you restore insulin sensitivity, you're better able to access and burn fat." — Dom D’Agostino

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Alzheimer’s disease and glucose metabolism

Peter Attia — Sun, 16 Feb 2020 12:45:18 +0000

"In Alzheimer’s Research, Glucose Metabolism Moves to Center Stage."

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#26 – AMA #3: supplements, women’s health, patient care, and more

Peter Attia — Mon, 29 Oct 2018 09:35:28 +0000

“In case you haven't guessed yet, there's been a lot of drug traffic on the beach. And I'm not talking about Robitussin and No-Doze. I'm talking about the hard stuff, and a lot of it. I've been trying to find out who's behind it. It hasn't been easy. I don't shower much.” —Irwin M. Fletcher

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