mTOR Archives - Peter Attia Wed, 29 Jan 2025 00:57:37 +0000 en-US hourly 1 https://peterattiamd.com/wp-content/uploads/2023/04/cropped-apple-icon-32x32.png mTOR Archives - Peter Attia 32 32 #329 ‒ Special AMA: Peter on exercise, important labs, building good habits, promising longevity research, and more https://peterattiamd.com/specialama/ Mon, 16 Dec 2024 09:00:00 +0000 https://peterattiamd.com/?p=31196 In this special episode of The Drive, Peter tackles a wide range of listener questions submitted over the past year. The discussion spans essential topics such as exercise—covering grip strength, traveling workouts, and why Peter doesn’t consider exercise an ideal weight-loss strategy—and the top biomarkers everyone should track. He also explores promising new longevity research,…

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]]> Is interleukin-11 a promising new target for lifespan-extending interventions? https://peterattiamd.com/interleukin-11-and-lifespan/ Sat, 07 Sep 2024 11:00:45 +0000 https://peterattiamd.com/?p=25783 A recent study reports impressive results in male and female mice with anti-IL-11 therapy

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]]> Do high protein diets increase cancer risk? https://peterattiamd.com/high-protein-diets-and-cancer-risk/ https://peterattiamd.com/high-protein-diets-and-cancer-risk/#comments Wed, 12 Jun 2024 14:00:00 +0000 https://peterattiamd.com/?p=25261 Is there any merit to the idea that consuming more protein increases one’s risk of developing or dying from cancer?

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]]> https://peterattiamd.com/high-protein-diets-and-cancer-risk/feed/ 11 Silencing the alarm over a recent paper on dietary protein and atherosclerosis https://peterattiamd.com/protein-and-ascvd/ Sat, 13 Apr 2024 11:00:17 +0000 https://peterattiamd.com/?p=24902 A recent report that high protein intake contributes to atherosclerosis has limited relevance to anyone but transgenic mice

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]]> #276 ‒ Special episode: Peter answers questions on longevity, supplements, protein, fasting, apoB, statins, and more https://peterattiamd.com/peter-faq/ https://peterattiamd.com/peter-faq/#comments Mon, 23 Oct 2023 08:45:56 +0000 https://peterattiamd.com/?p=22168 “One of the most important things to understand when you are using some sort of intervention is, do you have a biomarker to know if you're doing it correctly?” —Peter Attia

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]]> https://peterattiamd.com/peter-faq/feed/ 9 Could an antihypertensive drug have independent benefits for longevity? https://peterattiamd.com/rilmenidine-and-lifespan-extension/ Sat, 14 Oct 2023 11:00:34 +0000 https://peterattiamd.com/?p=22122 A recent animal study indicates that the antihypertensive drug rilmenidine has impressive effects on lifespan, but without further evidence, this story seems like another “fountain of youth” myth.

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]]> #272 ‒ Rapamycin: potential longevity benefits, surge in popularity, unanswered questions, and more | David Sabatini, M.D., Ph.D. and Matt Kaeberlein, Ph.D. https://peterattiamd.com/davidsabatini-mattkaeberlein/ https://peterattiamd.com/davidsabatini-mattkaeberlein/#comments Mon, 25 Sep 2023 08:45:33 +0000 https://peterattiamd.com/?p=22045 "[Rapamycin] is the most robust and reproducible drug that we know about today for impacting not only longevity, but to the extent that we can measure various metrics of healthspan in complex animals, rapamycin also seems to positively impact pretty much every aspect of health span that we measure.” —Matt Kaeberlein

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]]> https://peterattiamd.com/davidsabatini-mattkaeberlein/feed/ 5 The cases for and against dietary protein for healthy aging https://peterattiamd.com/dietary-protein-and-healthy-aging/ https://peterattiamd.com/dietary-protein-and-healthy-aging/#comments Wed, 26 Jul 2023 22:29:42 +0000 https://peterattiamd.com/?p=21633 An endeavor to settle the debate of high- vs. low-protein diets for increasing lifespan and healthspan

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]]> https://peterattiamd.com/dietary-protein-and-healthy-aging/feed/ 35 #222 ‒ How nutrition impacts longevity | Matt Kaeberlein, Ph.D. https://peterattiamd.com/mattkaeberlein3/ https://peterattiamd.com/mattkaeberlein3/#comments Mon, 12 Sep 2022 08:45:12 +0000 https://peterattiamd.com/?p=18753 “It's really important that we be willing to change our beliefs about nutrition and other aspects of health as more data comes in.” —Matt Kaeberlein

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]]> https://peterattiamd.com/mattkaeberlein3/feed/ 7 The challenges of defining aging with Matt Kaeberlein, Ph.D. https://peterattiamd.com/the-challenges-of-defining-aging/ Fri, 13 May 2022 17:03:29 +0000 https://peterattiamd.com/?p=18033 This video clip is from episode #175 – The biology of aging, rapamycin, and other interventions that target the aging process with Matt Kaeberlein, Ph.D., originally released on September 13, 2021.

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]]> #204 – Centenarians, metformin, and longevity | Nir Barzilai, M.D. https://peterattiamd.com/nirbarzilai2/ https://peterattiamd.com/nirbarzilai2/#comments Mon, 25 Apr 2022 08:45:21 +0000 https://peterattiamd.com/?p=17736 “If you prevent aging and age-related disease, you're going to compress morbidity, too.” — Nir Barzilai

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]]> https://peterattiamd.com/nirbarzilai2/feed/ 5 #175 – Matt Kaeberlein, Ph.D.: The biology of aging, rapamycin, and other interventions that target the aging process https://peterattiamd.com/mattkaeberlein2/ https://peterattiamd.com/mattkaeberlein2/#comments Mon, 13 Sep 2021 08:45:40 +0000 https://peterattiamd.com/?p=16112 “I don't think I will ever understand aging fully. And I don't think the field will. … But I also believe that we don't have to understand it fully to be able to have an impact on the biology of aging through interventions.” —Matt Kaeberlein

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]]> https://peterattiamd.com/mattkaeberlein2/feed/ 11 Rapamycin risks? https://peterattiamd.com/rapamycin-risks/ https://peterattiamd.com/rapamycin-risks/#comments Sun, 12 Sep 2021 09:45:26 +0000 https://peterattiamd.com/?p=16093 The importance of good science and good interpretation

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]]> https://peterattiamd.com/rapamycin-risks/feed/ 3 How long can we live?; suggested listening https://peterattiamd.com/how-long-can-we-live/ https://peterattiamd.com/how-long-can-we-live/#comments Sun, 01 Aug 2021 10:00:13 +0000 https://peterattiamd.com/?p=16025 Revisiting the podcast archive 

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]]> https://peterattiamd.com/how-long-can-we-live/feed/ 1 Rapamycin: one of my favorite stories; Ryan Lochte’s flip side on missing Olympic redemption https://peterattiamd.com/rapamycin-one-of-my-favorite-stories-ryan-lochtes-flip-side-on-missing-olympic-redemption/ https://peterattiamd.com/rapamycin-one-of-my-favorite-stories-ryan-lochtes-flip-side-on-missing-olympic-redemption/#comments Sun, 18 Jul 2021 10:00:25 +0000 https://peterattiamd.com/?p=15986 A few things worth checking out: 07-18-2021

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]]> https://peterattiamd.com/rapamycin-one-of-my-favorite-stories-ryan-lochtes-flip-side-on-missing-olympic-redemption/feed/ 3 #163 – Layne Norton, Ph.D.: Building muscle, losing fat, and the importance of resistance training https://peterattiamd.com/laynenorton/ https://peterattiamd.com/laynenorton/#comments Mon, 24 May 2021 08:45:39 +0000 https://peterattiamd.com/?p=15842 “I always tell people, I don't think I would've had the success I did in business or social media or academia if I hadn't done weightlifting because that taught me so much about other things in life.” —Layne Norton

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]]> https://peterattiamd.com/laynenorton/feed/ 6 A few things worth checking out: 12-13-2020 https://peterattiamd.com/a-few-things-worth-checking-out-12-13-2020/ https://peterattiamd.com/a-few-things-worth-checking-out-12-13-2020/#comments Sun, 13 Dec 2020 12:45:12 +0000 https://peterattiamd.com/?p=14627 COVID-19 vaccine concerns; visualizing cell signaling pathways; IQ points

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]]> https://peterattiamd.com/a-few-things-worth-checking-out-12-13-2020/feed/ 2 #118 – Lloyd Klickstein, M.D., Ph.D.: Rapamycin, mTOR inhibition, and the biology of aging https://peterattiamd.com/lloydklickstein/ https://peterattiamd.com/lloydklickstein/#comments Mon, 06 Jul 2020 09:45:43 +0000 https://peterattiamd.com/?p=13361 "Our approach is to address serious aging-associated diseases, and if we're successful, the side effect will be longevity." — Lloyd Klickstein

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]]> https://peterattiamd.com/lloydklickstein/feed/ 7 #116 – AMA with Dom D’Agostino, Ph.D., Part I of II: Ketogenic diet, exogenous ketones, and exercise https://peterattiamd.com/domdagostinoama01/ https://peterattiamd.com/domdagostinoama01/#comments Mon, 22 Jun 2020 09:45:12 +0000 https://peterattiamd.com/?p=13260 "If you restore insulin sensitivity, you're better able to access and burn fat." — Dom D’Agostino

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]]> https://peterattiamd.com/domdagostinoama01/feed/ 9 #114 – Eileen White, Ph.D.: Autophagy, fasting, and promising new cancer therapies https://peterattiamd.com/eileenwhite/ https://peterattiamd.com/eileenwhite/#comments Mon, 08 Jun 2020 09:45:00 +0000 https://peterattiamd.com/?p=13195 "I would like to translate what we've learned about the role of autophagy in cancer and that involves developing small molecules to inhibit autophagy for cancer therapy." — Eileen White

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]]> https://peterattiamd.com/eileenwhite/feed/ 14 Metformin and exercise – déjà vu all over again? https://peterattiamd.com/metformin-and-exercise-deja-vu-all-over-again/ https://peterattiamd.com/metformin-and-exercise-deja-vu-all-over-again/#comments Sun, 13 Oct 2019 11:45:56 +0000 https://peterattiamd.com/?p=9827 Metformin blunts muscle hypertrophy in response to progressive resistance training

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]]> https://peterattiamd.com/metformin-and-exercise-deja-vu-all-over-again/feed/ 11 Can you maintain muscle during fasting? https://peterattiamd.com/can-you-maintain-muscle-during-fasting/ https://peterattiamd.com/can-you-maintain-muscle-during-fasting/#comments Sun, 01 Sep 2019 15:55:16 +0000 https://peterattiamd.com/?p=9328 But in the short-term (at least up to a week for most people), I believe you can maintain muscle mass while fasting, particularly if you’re resistance training.

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]]> https://peterattiamd.com/can-you-maintain-muscle-during-fasting/feed/ 23 Targeting aging https://peterattiamd.com/targeting-aging/ https://peterattiamd.com/targeting-aging/#comments Sun, 28 Apr 2019 18:59:14 +0000 https://peterattiamd.com/?p=9088 Given that “TOR” is literally “Target of Rapamycin,” it’s no surprise that rapamycin may increase longevity.

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]]> https://peterattiamd.com/targeting-aging/feed/ 1 Wanna know what keeps me up at night? https://peterattiamd.com/wanna-know-what-keeps-me-up-at-night/ Sun, 20 Jan 2019 18:35:25 +0000 https://peterattiamd.com/?p=9065 Unfortunately, the answer is: We have no clue what the best protocol is for intermittent fasting (fasting that is done periodically, and not to be confused with time restricted feeding).

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