Neurodegeneration - Alzheimer's disease Archives - Peter Attia

#334 – Cardiovascular disease, the number one killer: development, biomarkers, apoB, cholesterol, brain health, and more | Tom Dayspring, M.D.

Peter Attia — Mon, 03 Feb 2025 05:15:00 +0000

“Cholesterol is almost certainly the most important molecule in the brain.” —Tom Dayspring

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#319 ‒ Peter’s key takeaways on liver health, heart rate variability, AI in medicine, klotho, and lactate metabolism | Quarterly Podcast Summary #2

Peter Attia — Mon, 30 Sep 2024 08:45:49 +0000

“In humans, klotho is indeed a longevity gene. More klotho from the gene means longer life, better cognition. Take it away, shorter life, worse cognition.” —Peter Attia

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#313 – AMA #62: Protein’s impact on appetite and weight management, and uric acid’s link to disease and how to manage levels

Peter Attia — Mon, 12 Aug 2024 08:45:11 +0000

"The body responds in pretty significant ways to alterations in protein availability.” —Peter Attia

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#309 ‒ AI in medicine: its potential to revolutionize disease prediction, diagnosis, and outcomes, causes for concern in medicine and beyond, and more | Isaac Kohane, M.D., Ph.D.

Peter Attia — Mon, 15 Jul 2024 08:45:54 +0000

“What I'm excited about is the opportunity for new businesses and new ways of delivering to patients insights that are data-driven.” —Zak Kohane

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#306 – AMA #60: preventing cognitive decline, nutrition myths, lowering blood glucose, apoB, and blood pressure, and more

Peter Attia — Mon, 17 Jun 2024 08:45:49 +0000

“Metabolic health, first and foremost, is the goal of nutrition.” —Peter Attia

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#303 – A breakthrough in Alzheimer’s disease: the promising potential of klotho for brain health, cognitive decline, and as a therapeutic tool for Alzheimer’s disease | Dena Dubal, M.D., Ph.D.

Peter Attia — Mon, 27 May 2024 08:45:09 +0000

“I have this dream that people might be able someday to benefit from klotho, this factor that naturally circulates in our body, that helps with longevity, that helps with other organ systems and enhances the brain.” —Dena Dubal

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Targeting senescent cells for cognitive health

Peter Attia — Sat, 13 Jan 2024 12:00:33 +0000

With the recent publication of the first clinical trial of senolytics for AD treatment, popular interest in these drugs has swelled, but is the excitement justified?

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#279 – AMA #53: Metabolic health & pharmacologic interventions: SGLT-2 inhibitors, metformin, GLP-1 agonists, and the impact of statins

Peter Attia — Mon, 13 Nov 2023 09:45:23 +0000

“It is worth noting, and this is a very important question, that it does not appear that the effect of statins on insulin resistance is a function of lipids being lowered.” —Peter Attia

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#257 ‒ Cognitive decline, neurodegeneration, and head injuries: mitigation and prevention strategies, supplements, and more | Tommy Wood, M.D., Ph.D.

Peter Attia — Mon, 05 Jun 2023 08:45:36 +0000

"If you're trying to maintain a basic set of cognitive functions, [it is important] to actively work on ways to increase headroom, increase absolute capacity throughout the lifespan. Because at some point capacity will decrease, but you want to push that out as far as you can." —Tommy Wood

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#255 ‒ Latest therapeutics in CVD, APOE’s role in Alzheimer’s disease and CVD, familial hypercholesterolemia, and more | John Kastelein, M.D., Ph.D.

Peter Attia — Mon, 22 May 2023 08:45:50 +0000

“One of the things that is so dangerous about this disorder is that the plaque that you get in FH is a soft plaque.” —John Kastelein

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#252 ‒ Latest insights on Alzheimer’s disease, cancer, exercise, nutrition, and fasting | Rhonda Patrick, Ph.D.

Peter Attia — Mon, 01 May 2023 08:45:03 +0000

“My perspective has shifted as any scientist that's following data should… When new data comes out, you have to reassess things.” —Rhonda Patrick

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#251 – AMA #46: Optimizing brain health: Alzheimer’s disease risk factors, APOE, prevention strategies, and more

Peter Attia — Mon, 17 Apr 2023 08:45:56 +0000

“The bottom line here is the earlier you were diagnosed with type 2 diabetes, the higher your risk of dementia.” —Peter Attia

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#240 ‒ The confusion around HDL and its link to cardiovascular disease | Dan Rader, M.D.

Peter Attia — Mon, 30 Jan 2023 09:45:08 +0000

“HDL cholesterol itself is not directly and causally protective against atherosclerotic cardiovascular disease.” —Dan Rader

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Non-caffeine components of coffee and their effects on neurodegenerative diseases

Peter Attia — Sat, 14 Jan 2023 12:00:10 +0000

Coffee consumption is associated with reduced risk of Alzheimer’s disease and other neurodegenerative processes, but the effect may be more than a matter of caffeine.

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Can an annual flu vaccine reduce your risk of Alzheimer’s disease?

Peter Attia — Sat, 12 Nov 2022 12:00:59 +0000

A recent retrospective study suggests that flu vaccines reduce risk of Alzheimer’s disease, but the study raises as many questions as it answers.

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Adding context to the Alzheimer’s disease research fraud charges

Peter Attia — Sat, 03 Sep 2022 11:00:11 +0000

This past July, a news article published in Science sent shockwaves through the scientific community when it reported that one of the most influential and frequently-cited publications in Alzheimer’s disease (AD) research was evidently based on fraud.

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Alzheimer’s disease — what labs can tell you about your risk

Peter Attia — Fri, 29 Jul 2022 13:00:25 +0000

This clip is from AMA #14: What lab tests can (and cannot) inform us about our overall objective of longevity, originally released on May 18, 2020.

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Why does Alzheimer’s disease affect more women than men?

Peter Attia — Wed, 27 Jul 2022 13:00:26 +0000

This clip is from episode #138 – Lauren Miller Rogen and Richard Isaacson, M.D.: Alzheimer’s disease prevention—patient and doctor perspectives, originally released on November 23, 2020.

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The connection between sleep and Alzheimer’s disease

Peter Attia — Wed, 20 Jul 2022 13:00:14 +0000

This audio clip is from episode #47 – Matthew Walker, Ph.D., on sleep – Part I of III: Dangers of poor sleep, Alzheimer’s risk, mental health, memory consolidation, and more, originally released on April 1, 2019.

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Does exercise reduce the risk of Alzheimer’s disease?

Peter Attia — Tue, 28 Jun 2022 13:00:15 +0000

This clip is from episode #18 – Richard Isaacson, M.D.: Alzheimer’s prevention, originally release on October 1, 2018.

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Peter on the four horsemen of chronic disease

Peter Attia — Wed, 20 Apr 2022 11:00:26 +0000

This audio clip is from AMA #14: What lab tests can (and cannot) inform us about our overall objective of longevity, originally released on May 18, 2020. If you’re a subscriber, you can now listen to this full episode on your private RSS feed or on our website at the AMA #14 show notes page.…

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Peter on Alzheimer’s disease prevention and the latest on APOE4

Peter Attia — Tue, 12 Apr 2022 00:00:37 +0000

This clip is from episode #202, Peter on nutrition, disease prevention, sleep, and more, originally released on April 11, 2022.

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#202 – Peter on nutrition, disease prevention, sleep, and more — looking back on the last 100 episodes

Peter Attia — Mon, 11 Apr 2022 08:45:15 +0000

“I really think that in 10 years we're going to basically be using designer-based immunotherapies to eradicate most solid organ metastatic cancers.” —Peter Attia

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Low LDL cholesterol and neural development

Peter Attia — Sat, 05 Feb 2022 15:00:43 +0000

Why LDL-lowering treatments don’t pit head against heart

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