Longevity medications & supplements Archives - Peter Attia https://peterattiamd.com/category/longevity/longevity-medications-supplements/ Tue, 25 Feb 2025 23:45:09 +0000 en-US hourly 1 https://peterattiamd.com/wp-content/uploads/2023/04/cropped-apple-icon-32x32.png Longevity medications & supplements Archives - Peter Attia https://peterattiamd.com/category/longevity/longevity-medications-supplements/ 32 32 Metformin as a potential longevity medication: where do we stand? https://peterattiamd.com/metformin-and-longevity/ Wed, 26 Feb 2025 13:00:00 +0000 https://peterattiamd.com/?p=32916 Hype over metformin’s longevity effects has waxed and waned, with a recent boost from a high-profile study. How should we think about this evidence?

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]]> #333 ‒ Longevity roundtable — the science of aging, geroprotective molecules, lifestyle interventions, challenges in research, and more | Steven Austad, Ph.D., Matt Kaeberlein, Ph.D., Richard Miller, M.D., Ph.D. https://peterattiamd.com/longevityroundtable/ Mon, 27 Jan 2025 05:15:00 +0000 https://peterattiamd.com/?p=31978 “The notion that aging is not malleable, though wrong and provably wrong, is still the overwhelming opinion even of reasonably educated scientists and certainly of the lay public.” ‒ Rich Miller

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]]> #329 ‒ Special AMA: Peter on exercise, important labs, building good habits, promising longevity research, and more https://peterattiamd.com/specialama/ Mon, 16 Dec 2024 09:00:00 +0000 https://peterattiamd.com/?p=31196 In this special episode of The Drive, Peter tackles a wide range of listener questions submitted over the past year. The discussion spans essential topics such as exercise—covering grip strength, traveling workouts, and why Peter doesn’t consider exercise an ideal weight-loss strategy—and the top biomarkers everyone should track. He also explores promising new longevity research,…

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]]> Evaluating NAD and NAD precursors for health and longevity https://peterattiamd.com/nad-for-health-and-longevity/ https://peterattiamd.com/nad-for-health-and-longevity/#comments Wed, 11 Dec 2024 23:07:16 +0000 https://peterattiamd.com/?p=31113 NAD and its precursors – mainly NR and NMN – have garnered attention for numerous purported benefits, but which are supported by evidence?

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]]> https://peterattiamd.com/nad-for-health-and-longevity/feed/ 2 Failure of resveratrol to improve metabolic health is another nail in the coffin for the alleged “anti-aging” compound https://peterattiamd.com/resveratrol-and-metabolic-health/ Sat, 26 Oct 2024 11:00:12 +0000 https://peterattiamd.com/?p=28072 A recent meta-analysis of randomized trials assessed the performance of resveratrol in improving various metrics of metabolic health

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]]> #300 – Special episode: Peter on exercise, fasting, nutrition, stem cells, geroprotective drugs, and more — promising interventions or just noise? https://peterattiamd.com/ep-300-exercise-nutrition-fasting-more/ https://peterattiamd.com/ep-300-exercise-nutrition-fasting-more/#comments Mon, 06 May 2024 08:45:12 +0000 https://peterattiamd.com/?p=25063 “The probability that having a high VO2 max, high muscle mass, and high muscle strength are going to increase the length of your life and improve the quality of your life. . .is so high that to act in disregard of that is irresponsible.” —Peter Attia

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]]> https://peterattiamd.com/ep-300-exercise-nutrition-fasting-more/feed/ 23 #281 ‒ Longevity drugs, aging biomarkers, and updated findings from the Interventions Testing Program (ITP) | Rich Miller, M.D., Ph.D. https://peterattiamd.com/richardmiller2/ https://peterattiamd.com/richardmiller2/#comments Mon, 04 Dec 2023 09:45:47 +0000 https://peterattiamd.com/?p=22338 “What we try to do is quite simple. We try to find drugs that will slow aging and extend mouse lifespan.” —Rich Miller

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]]> https://peterattiamd.com/richardmiller2/feed/ 4 Could an antihypertensive drug have independent benefits for longevity? https://peterattiamd.com/rilmenidine-and-lifespan-extension/ Sat, 14 Oct 2023 11:00:34 +0000 https://peterattiamd.com/?p=22122 A recent animal study indicates that the antihypertensive drug rilmenidine has impressive effects on lifespan, but without further evidence, this story seems like another “fountain of youth” myth.

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]]> #246 – AMA #45: Pros and cons of GLP-1 weight loss drugs and metformin as a geroprotective agent https://peterattiamd.com/ama45/ https://peterattiamd.com/ama45/#comments Mon, 13 Mar 2023 08:45:43 +0000 https://peterattiamd.com/?p=20438 "The thing that concerns me the most with these drugs. . .is this drive towards sarcopenia.” —Peter Attia

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]]> https://peterattiamd.com/ama45/feed/ 6 A recent metformin study casts doubts on longevity indications https://peterattiamd.com/a-recent-metformin-study-casts-doubts-on-longevity-indications/ Sat, 11 Mar 2023 12:00:18 +0000 https://peterattiamd.com/?p=20388 A new retrospective study contradicts previous evidence of metformin’s potential effects on lifespan extension in a general population, but for real answers, randomized trials are needed.

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]]> The difference between a ‘clean’ drug and a ‘dirty’ drug https://peterattiamd.com/the-difference-between-a-clean-drug-and-a-dirty-drug/ Tue, 14 Jun 2022 18:42:45 +0000 https://peterattiamd.com/?p=18280 This clip is from episode #207 – AMA #35: “Anti-Aging” Drugs — NAD+, metformin, & rapamycin, originally released on May 16, 2022. If you’re not a subscriber and listening on a podcast player, you’ll only be able to hear a preview of the AMA. If you’re a subscriber, you can now listen to this full…

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]]> Are there “biomarkers” for aging? https://peterattiamd.com/are-there-biomarkers-for-aging/ Thu, 26 May 2022 14:48:40 +0000 https://peterattiamd.com/?p=18118 This clip is from “Ask Me Anything” (AMA) episode #35, originally released on May 16, 2022. If you’re a member, you can now listen to this full episode on your private RSS feed or on our website. If you are not a member, learn more about the how to become a member and the benefits here.

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]]> #207 – AMA #35: “Anti-Aging” Drugs — NAD+, metformin, & rapamycin https://peterattiamd.com/ama35/ https://peterattiamd.com/ama35/#comments Mon, 16 May 2022 08:45:28 +0000 https://peterattiamd.com/?p=17994 “It's really hard to know, in my view, how important sirtuins are as longevity factors…If we accept that, then it's difficult to know [the importance of] activation of sirtuins by NAD as a longevity mechanism.” —Matt Kaeberlein

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]]> https://peterattiamd.com/ama35/feed/ 1 The challenges of defining aging with Matt Kaeberlein, Ph.D. https://peterattiamd.com/the-challenges-of-defining-aging/ Fri, 13 May 2022 17:03:29 +0000 https://peterattiamd.com/?p=18033 This video clip is from episode #175 – The biology of aging, rapamycin, and other interventions that target the aging process with Matt Kaeberlein, Ph.D., originally released on September 13, 2021.

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]]> Potential Risks of NAD Supplements with Iñigo San-Millán, Ph.D. https://peterattiamd.com/potential-risks-of-nad-supplements/ Fri, 13 May 2022 15:58:46 +0000 https://peterattiamd.com/?p=18031 This video clip is from episode #201 – Deep dive back into Zone 2 with Iñigo San-Millán, Ph.D. (Pt. 2), originally released on March 28, 2022.

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]]> About TAME: A Metformin Anti-Aging Clinical Trial with Nir Barzilai, M.D. https://peterattiamd.com/tame-metformin-anti-aging-trial-nir-barzilai/ https://peterattiamd.com/tame-metformin-anti-aging-trial-nir-barzilai/#comments Fri, 13 May 2022 15:55:49 +0000 https://peterattiamd.com/?p=18032 This video clip is from episode #204 – Centenarians, metformin, and longevity with Nir Barzilai, M.D., originally released on April 25, 2022.

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]]> https://peterattiamd.com/tame-metformin-anti-aging-trial-nir-barzilai/feed/ 1 #204 – Centenarians, metformin, and longevity | Nir Barzilai, M.D. https://peterattiamd.com/nirbarzilai2/ https://peterattiamd.com/nirbarzilai2/#comments Mon, 25 Apr 2022 08:45:21 +0000 https://peterattiamd.com/?p=17736 “If you prevent aging and age-related disease, you're going to compress morbidity, too.” — Nir Barzilai

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]]> https://peterattiamd.com/nirbarzilai2/feed/ 5 #175 – Matt Kaeberlein, Ph.D.: The biology of aging, rapamycin, and other interventions that target the aging process https://peterattiamd.com/mattkaeberlein2/ https://peterattiamd.com/mattkaeberlein2/#comments Mon, 13 Sep 2021 08:45:40 +0000 https://peterattiamd.com/?p=16112 “I don't think I will ever understand aging fully. And I don't think the field will. … But I also believe that we don't have to understand it fully to be able to have an impact on the biology of aging through interventions.” —Matt Kaeberlein

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]]> https://peterattiamd.com/mattkaeberlein2/feed/ 11 Funding geroscience; suggested podcast listening https://peterattiamd.com/funding-geroscience-suggested-podcast-listening/ Sun, 29 Aug 2021 12:52:19 +0000 https://peterattiamd.com/?p=16071 Revisiting the podcast archive

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]]> How long can we live?; suggested listening https://peterattiamd.com/how-long-can-we-live/ https://peterattiamd.com/how-long-can-we-live/#comments Sun, 01 Aug 2021 10:00:13 +0000 https://peterattiamd.com/?p=16025 Revisiting the podcast archive 

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]]> https://peterattiamd.com/how-long-can-we-live/feed/ 1 #148 – Richard Miller, M.D., Ph.D.: The gold standard for testing longevity drugs: the Interventions Testing Program https://peterattiamd.com/richardmiller/ https://peterattiamd.com/richardmiller/#comments Mon, 08 Feb 2021 10:45:56 +0000 https://peterattiamd.com/?p=14787 “I don't really care what causes aging. What I care about is: What is the process that can postpone all the different aspects of aging?” — Rich Miller

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]]> https://peterattiamd.com/richardmiller/feed/ 13 Q&A on Alzheimer’s disease drug therapy with Dr. Richard Isaacson https://peterattiamd.com/qa-with-dr-richard-isaacson-on-aducanumab-alzheimers-disease-drug-therapy/ Sun, 22 Nov 2020 12:45:49 +0000 https://peterattiamd.com/?p=14578 Check out more content with neurologist, Richard Isaacson, M.D.: (Oct 1, 2018) #18 – Richard Isaacson, M.D.: Alzheimer’s prevention (Nov 22, 2020) Q&A on Alzheimer’s disease drug therapy with Dr. Richard Isaacson (Nov 23, 2020) #138 – Lauren Miller Rogen and Richard Isaacson, M.D.: Alzheimer’s disease prevention—patient and doctor perspectives The topic of Alzheimer’s disease…

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]]> #132 – AMA #16: Exploring hot and cold therapy https://peterattiamd.com/ama16/ https://peterattiamd.com/ama16/#comments Mon, 12 Oct 2020 09:45:34 +0000 https://peterattiamd.com/?p=14444 "All of the work that went into this analysis earlier in the year, it really changed my tune. And I think I'm now at the point where I kind of want to have a sauna, frankly, in the tool kit for longevity." — Peter Attia

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]]> https://peterattiamd.com/ama16/feed/ 16 A few things worth sharing: 10-04-2020 https://peterattiamd.com/a-few-things-worth-sharing-10-04-2020/ https://peterattiamd.com/a-few-things-worth-sharing-10-04-2020/#comments Sun, 04 Oct 2020 11:45:58 +0000 https://peterattiamd.com/?p=13920 Longevity in mice; The wonders of F1.

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